Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2640860..2641785 Replicon chromosome
Accession NZ_CP106743
Organism Pseudomonas aeruginosa strain PALA15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PALA15_RS12465 Protein ID WP_033979787.1
Coordinates 2641603..2641785 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PALA15_RS12460 Protein ID WP_016561976.1
Coordinates 2640860..2641555 (-) Length 232 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA15_RS12420 2635888..2636070 + 183 WP_124136131.1 hypothetical protein -
PALA15_RS12425 (PALA15_02468) 2636105..2636956 - 852 WP_021263391.1 S24 family peptidase -
PALA15_RS12430 2637057..2637275 + 219 WP_016561979.1 Cro/CI family transcriptional regulator -
PALA15_RS12435 (PALA15_02469) 2637307..2637879 + 573 WP_016046669.1 hypothetical protein -
PALA15_RS12440 2637882..2638766 + 885 WP_033979793.1 hypothetical protein -
PALA15_RS12445 (PALA15_02470) 2638669..2639424 + 756 WP_238568662.1 replication protein P -
PALA15_RS12450 (PALA15_02471) 2639417..2639860 + 444 WP_033979790.1 RusA family crossover junction endodeoxyribonuclease -
PALA15_RS12455 (PALA15_02472) 2639889..2640758 + 870 WP_033979789.1 hypothetical protein -
PALA15_RS12460 (PALA15_02473) 2640860..2641555 - 696 WP_016561976.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PALA15_RS12465 (PALA15_02474) 2641603..2641785 - 183 WP_033979787.1 type II toxin-antitoxin system HicA family toxin Toxin
PALA15_RS12470 (PALA15_02475) 2641985..2642320 + 336 WP_003119044.1 phage holin, lambda family -
PALA15_RS12475 (PALA15_02476) 2642317..2642934 + 618 WP_033979786.1 glycoside hydrolase family 19 protein -
PALA15_RS12480 (PALA15_02477) 2642952..2643383 + 432 WP_174220302.1 hypothetical protein -
PALA15_RS12485 (PALA15_02478) 2643480..2644217 + 738 WP_033979785.1 hypothetical protein -
PALA15_RS12490 (PALA15_02479) 2644432..2644977 + 546 WP_031627904.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2615253..2665536 50283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.85 Da        Isoelectric Point: 11.0775

>T259668 WP_033979787.1 NZ_CP106743:c2641785-2641603 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGGHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGFK

Download         Length: 183 bp

Antitoxin


Download         Length: 232 a.a.        Molecular weight: 25958.40 Da        Isoelectric Point: 4.8091

>AT259668 WP_016561976.1 NZ_CP106743:c2641555-2640860 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSASGVAVFCRDLPELNSFGDDREHAIREALDAIETTLSLYVDARKPIPEATPPEEGEHVVHLPSVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHTSKMEALESALAALDTKLTVRASYGNNVVKLRYMANTARGRVL
VIPGDADPKALPRQYEWLQEAPCRIEETVDDFEVGARYAMWNVEEAVNAIQSRGYFSFWLETTSGPRSATR

Download         Length: 696 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References