Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1836092..1837600 Replicon chromosome
Accession NZ_CP106743
Organism Pseudomonas aeruginosa strain PALA15

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA15_RS08500 Protein ID WP_003119682.1
Coordinates 1836092..1836679 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PALA15_RS08505 Protein ID WP_003091607.1
Coordinates 1836746..1837600 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA15_RS08495 (PALA15_01687) 1832347..1835826 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA15_RS08500 (PALA15_01688) 1836092..1836679 + 588 WP_003119682.1 GNAT family protein Toxin
PALA15_RS08505 (PALA15_01689) 1836746..1837600 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PALA15_RS08510 (PALA15_01690) 1837697..1839862 + 2166 WP_023130797.1 TonB-dependent receptor family protein -
PALA15_RS08515 (PALA15_01691) 1840037..1841911 + 1875 WP_010793244.1 MFS transporter -
PALA15_RS08520 (PALA15_01692) 1841972..1842181 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T259667 WP_003119682.1 NZ_CP106743:1836092-1836679 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT259667 WP_003091607.1 NZ_CP106743:1836746-1837600 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References