Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1572538..1574233 Replicon chromosome
Accession NZ_CP106743
Organism Pseudomonas aeruginosa strain PALA15

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA15_RS07265 Protein ID WP_003112901.1
Coordinates 1572538..1573407 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA15_RS07270 Protein ID WP_003112902.1
Coordinates 1573400..1574233 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA15_RS07240 (PALA15_01439) 1568546..1569397 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA15_RS07245 (PALA15_01440) 1569438..1570445 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
PALA15_RS07250 (PALA15_01441) 1570442..1571218 + 777 WP_003112898.1 ABC transporter permease -
PALA15_RS07255 (PALA15_01442) 1571224..1571985 + 762 WP_003112899.1 SDR family oxidoreductase -
PALA15_RS07260 (PALA15_01443) 1571999..1572529 + 531 WP_003112900.1 cupin domain-containing protein -
PALA15_RS07265 (PALA15_01444) 1572538..1573407 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA15_RS07270 (PALA15_01445) 1573400..1574233 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA15_RS07275 (PALA15_01446) 1574220..1575017 + 798 WP_017001845.1 SDR family oxidoreductase -
PALA15_RS07280 (PALA15_01447) 1575010..1576692 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA15_RS07285 (PALA15_01448) 1576703..1577506 + 804 WP_003453564.1 aspartate dehydrogenase -
PALA15_RS07290 (PALA15_01449) 1577518..1579002 + 1485 WP_017001843.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T259666 WP_003112901.1 NZ_CP106743:1572538-1573407 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT259666 WP_003112902.1 NZ_CP106743:1573400-1574233 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References