259663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4964971..4965524 Replicon chromosome
Accession NZ_CP106742
Organism Pseudomonas aeruginosa strain PALA14

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag PALA14_RS23505 Protein ID WP_010953434.1
Coordinates 4964971..4965264 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag PALA14_RS23510 Protein ID WP_010953433.1
Coordinates 4965252..4965524 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA14_RS23495 (PALA14_04623) 4960350..4963130 - 2781 WP_023464835.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
PALA14_RS23500 (PALA14_04624) 4963568..4964977 + 1410 WP_010953435.1 site-specific integrase -
PALA14_RS23505 4964971..4965264 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA14_RS23510 (PALA14_04625) 4965252..4965524 - 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
PALA14_RS23515 (PALA14_04626) 4965649..4965894 - 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PALA14_RS23520 (PALA14_04627) 4966099..4966428 + 330 WP_010953431.1 hypothetical protein -
PALA14_RS23525 (PALA14_04628) 4966526..4967494 + 969 WP_031299399.1 DUF932 domain-containing protein -
PALA14_RS23530 (PALA14_04629) 4967574..4968578 + 1005 WP_010953429.1 YqaJ viral recombinase family protein -
PALA14_RS23535 (PALA14_04630) 4968671..4969621 + 951 WP_031299400.1 hypothetical protein -
PALA14_RS23540 (PALA14_04631) 4969593..4969952 + 360 Protein_4647 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4939629..4994938 55309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T259663 WP_010953434.1 NZ_CP106742:c4965264-4964971 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT259663 WP_010953433.1 NZ_CP106742:c4965524-4965252 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References