259662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3723513..3724734 Replicon chromosome
Accession NZ_CP106742
Organism Pseudomonas aeruginosa strain PALA14

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA14_RS17970 Protein ID WP_003102740.1
Coordinates 3723513..3724091 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA14_RS17975 Protein ID WP_003088112.1
Coordinates 3724180..3724734 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA14_RS17955 (PALA14_03519) 3718789..3720066 + 1278 WP_003102743.1 TolC family protein -
PALA14_RS17960 (PALA14_03520) 3720056..3722227 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA14_RS17965 (PALA14_03521) 3722217..3723404 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA14_RS17970 (PALA14_03522) 3723513..3724091 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA14_RS17975 (PALA14_03523) 3724180..3724734 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA14_RS17980 (PALA14_03524) 3724892..3727087 - 2196 WP_023464651.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA14_RS17985 (PALA14_03525) 3727092..3727553 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA14_RS17990 (PALA14_03526) 3727884..3728207 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA14_RS17995 (PALA14_03527) 3728220..3728618 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
PALA14_RS18000 (PALA14_03528) 3728615..3729166 - 552 WP_003450159.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259662 WP_003102740.1 NZ_CP106742:c3724091-3723513 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259662 WP_003088112.1 NZ_CP106742:c3724734-3724180 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References