Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2653428..2654686 Replicon chromosome
Accession NZ_CP106742
Organism Pseudomonas aeruginosa strain PALA14

Toxin (Protein)


Gene name - Uniprot ID A0A241XTS2
Locus tag PALA14_RS12615 Protein ID WP_023464370.1
Coordinates 2653931..2654686 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A241XST8
Locus tag PALA14_RS12610 Protein ID WP_023464369.1
Coordinates 2653428..2653796 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA14_RS12590 2649592..2649867 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
PALA14_RS12595 (PALA14_02479) 2649870..2650346 - 477 WP_019725934.1 hypothetical protein -
PALA14_RS12600 (PALA14_02480) 2650424..2652013 + 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PALA14_RS12605 (PALA14_02481) 2652069..2653355 + 1287 WP_023464368.1 FAD-binding oxidoreductase -
PALA14_RS12610 (PALA14_02482) 2653428..2653796 + 369 WP_023464369.1 DUF2384 domain-containing protein Antitoxin
PALA14_RS12615 (PALA14_02483) 2653931..2654686 + 756 WP_023464370.1 RES family NAD+ phosphorylase Toxin
PALA14_RS12620 (PALA14_02484) 2655456..2656817 + 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA14_RS12625 (PALA14_02485) 2656972..2659515 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28226.37 Da        Isoelectric Point: 7.6839

>T259661 WP_023464370.1 NZ_CP106742:2653931-2654686 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.68 Da        Isoelectric Point: 9.9874

>AT259661 WP_023464369.1 NZ_CP106742:2653428-2653796 [Pseudomonas aeruginosa]
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XTS2

Antitoxin

Source ID Structure
AlphaFold DB A0A241XST8

References