259660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2578209..2578795 Replicon chromosome
Accession NZ_CP106742
Organism Pseudomonas aeruginosa strain PALA14

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA14_RS12205 Protein ID WP_003120987.1
Coordinates 2578209..2578508 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA14_RS12210 Protein ID WP_003448662.1
Coordinates 2578505..2578795 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA14_RS12185 (PALA14_02400) 2573322..2573855 - 534 WP_003099760.1 type IV pilus biogenesis protein PilP -
PALA14_RS12190 (PALA14_02401) 2573845..2575170 - 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PALA14_RS12195 (PALA14_02402) 2575174..2576883 - 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PALA14_RS12200 (PALA14_02403) 2576883..2578007 - 1125 WP_012076859.1 TcpQ domain-containing protein -
PALA14_RS12205 (PALA14_02404) 2578209..2578508 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA14_RS12210 (PALA14_02405) 2578505..2578795 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA14_RS12215 2578866..2579210 - 345 WP_016851612.1 hypothetical protein -
PALA14_RS12220 (PALA14_02406) 2579351..2581327 - 1977 WP_016851611.1 DEAD/DEAH box helicase -
PALA14_RS12225 (PALA14_02407) 2581324..2583213 - 1890 WP_016851610.1 hypothetical protein -
PALA14_RS12230 (PALA14_02408) 2583435..2583644 - 210 WP_003105733.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2513859..2606686 92827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T259660 WP_003120987.1 NZ_CP106742:2578209-2578508 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT259660 WP_003448662.1 NZ_CP106742:2578505-2578795 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References