Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 74312..74924 Replicon plasmid unnamed2
Accession NZ_CP106737
Organism Roseovarius sp. HL-MP18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N7U68_RS00335 Protein ID WP_263046739.1
Coordinates 74312..74707 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N7U68_RS00340 Protein ID WP_263046740.1
Coordinates 74697..74924 (-) Length 76 a.a.

Genomic Context

N7U68_RS00315N7U68_RS00330N7U68_RS00345N7U68_RS00350N7U68_RS00355N7U68_RS00305N7U68_RS00310N7U68_RS00320N7U68_RS00325N7U68_RS00335N7U68_RS00340
Location: 71566..72675 (1110 bp)
Type: Others
Protein ID: WP_263046737.1
Location: 73357..74250 (894 bp)
Type: Others
Protein ID: WP_263046738.1
Location: 75616..76800 (1185 bp)
Type: Others
Protein ID: WP_263046741.1
Location: 76800..77771 (972 bp)
Type: Others
Protein ID: WP_263046742.1
Location: 78012..79307 (1296 bp)
Type: Others
Protein ID: WP_263046743.1
Location: 69884..70420 (537 bp)
Type: Others
Protein ID: WP_263046777.1
Location: 70499..71452 (954 bp)
Type: Others
Protein ID: WP_263046736.1
Location: 72680..73003 (324 bp)
Type: Others
Protein ID: WP_165198350.1
Location: 72990..73235 (246 bp)
Type: Others
Protein ID: WP_165198351.1
Location: 74312..74707 (396 bp)
Type: Toxin
Protein ID: WP_263046739.1
Location: 74697..74924 (228 bp)
Type: Antitoxin
Protein ID: WP_263046740.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N7U68_RS00305 (N7U68_00305)69884..70420-537WP_263046777.1SMC-Scp complex subunit ScpB-
N7U68_RS00310 (N7U68_00310)70499..71452-954WP_263046736.1DUF1403 family protein-
N7U68_RS00315 (N7U68_00315)71566..72675+1110WP_263046737.1tyrosine-type recombinase/integrase-
N7U68_RS00320 (N7U68_00320)72680..73003-324WP_165198350.1type II toxin-antitoxin system RelE/ParE family toxin-
N7U68_RS00325 (N7U68_00325)72990..73235-246WP_165198351.1type II toxin-antitoxin system ParD family antitoxin-
N7U68_RS00330 (N7U68_00330)73357..74250+894WP_263046738.1recombinase family protein-
N7U68_RS00335 (N7U68_00335)74312..74707-396WP_263046739.1PIN domain-containing proteinToxin
N7U68_RS00340 (N7U68_00340)74697..74924-228WP_263046740.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
N7U68_RS00345 (N7U68_00345)75616..76800+1185WP_263046741.1plasmid partitioning protein RepA-
N7U68_RS00350 (N7U68_00350)76800..77771+972WP_263046742.1plasmid partitioning protein RepB-
N7U68_RS00355 (N7U68_00355)78012..79307+1296WP_263046743.1plasmid replication protein RepC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..242241242241
-flankIS/Tn--69003..69728725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14286.30 Da        Isoelectric Point: 4.1547

>T259656 WP_263046739.1 NZ_CP106737:c74707-74312 [Roseovarius sp. HL-MP18]
MSAEFADTNVVLYLLDDGPKADRAEDILGQGPRISVQVLNEAMVNCRRKAGLSWEETGAFLAGVQSLCPVEDLSVQTHLV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEDQLRVMNPFT

Download         Length: 396 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8575.85 Da        Isoelectric Point: 10.8838

>AT259656 WP_263046740.1 NZ_CP106737:c74924-74697 [Roseovarius sp. HL-MP18]
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLVKDDRTILVKRQPRADEVLQGLRRFRGQLSKDARLSRDAAHER

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References