Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 74312..74924 Replicon plasmid unnamed2
Accession NZ_CP106737
Organism Roseovarius sp. HL-MP18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N7U68_RS00335 Protein ID WP_263046739.1
Coordinates 74312..74707 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N7U68_RS00340 Protein ID WP_263046740.1
Coordinates 74697..74924 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7U68_RS00305 (N7U68_00305) 69884..70420 - 537 WP_263046777.1 SMC-Scp complex subunit ScpB -
N7U68_RS00310 (N7U68_00310) 70499..71452 - 954 WP_263046736.1 DUF1403 family protein -
N7U68_RS00315 (N7U68_00315) 71566..72675 + 1110 WP_263046737.1 tyrosine-type recombinase/integrase -
N7U68_RS00320 (N7U68_00320) 72680..73003 - 324 WP_165198350.1 type II toxin-antitoxin system RelE/ParE family toxin -
N7U68_RS00325 (N7U68_00325) 72990..73235 - 246 WP_165198351.1 type II toxin-antitoxin system ParD family antitoxin -
N7U68_RS00330 (N7U68_00330) 73357..74250 + 894 WP_263046738.1 recombinase family protein -
N7U68_RS00335 (N7U68_00335) 74312..74707 - 396 WP_263046739.1 PIN domain-containing protein Toxin
N7U68_RS00340 (N7U68_00340) 74697..74924 - 228 WP_263046740.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N7U68_RS00345 (N7U68_00345) 75616..76800 + 1185 WP_263046741.1 plasmid partitioning protein RepA -
N7U68_RS00350 (N7U68_00350) 76800..77771 + 972 WP_263046742.1 plasmid partitioning protein RepB -
N7U68_RS00355 (N7U68_00355) 78012..79307 + 1296 WP_263046743.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..242241 242241
- flank IS/Tn - - 69003..69728 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14286.30 Da        Isoelectric Point: 4.1547

>T259656 WP_263046739.1 NZ_CP106737:c74707-74312 [Roseovarius sp. HL-MP18]
MSAEFADTNVVLYLLDDGPKADRAEDILGQGPRISVQVLNEAMVNCRRKAGLSWEETGAFLAGVQSLCPVEDLSVQTHLV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEDQLRVMNPFT

Download         Length: 396 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8575.85 Da        Isoelectric Point: 10.8838

>AT259656 WP_263046740.1 NZ_CP106737:c74924-74697 [Roseovarius sp. HL-MP18]
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLVKDDRTILVKRQPRADEVLQGLRRFRGQLSKDARLSRDAAHER

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References