25965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/-
Location 4806232..4806808 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag SL1344_RS23235 Protein ID WP_001131963.1
Coordinates 4806232..4806519 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag SL1344_RS23240 Protein ID WP_000063142.1
Coordinates 4806506..4806808 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS23225 (SL1344_4457) 4801342..4804851 - 3510 WP_001043484.1 type I restriction-modification system endonuclease -
SL1344_RS23230 (SL1344_4458) 4805049..4805963 + 915 WP_000290512.1 restriction endonuclease -
SL1344_RS23235 (SL1344_4459) 4806232..4806519 + 288 WP_001131963.1 BrnT family toxin Toxin
SL1344_RS23240 (SL1344_4460) 4806506..4806808 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
SL1344_RS23245 (SL1344_4461) 4806883..4807839 - 957 WP_000187839.1 GTPase -
SL1344_RS23250 (SL1344_4462) 4807850..4808053 - 204 WP_000460616.1 YbdD/YjiX family protein -
SL1344_RS23255 (SL1344_4463) 4808148..4810298 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T25965 WP_001131963.1 NC_016810:4806232-4806519 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T25965 NC_016810:4806232-4806519 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT25965 WP_000063142.1 NC_016810:4806506-4806808 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT25965 NC_016810:4806506-4806808 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References