259649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3728862..3729904 Replicon chromosome
Accession NZ_CP106682
Organism Pseudomonas aeruginosa strain PALA13

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA13_RS17305 Protein ID WP_003050248.1
Coordinates 3728862..3729437 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA13_RS17310 Protein ID WP_003050245.1
Coordinates 3729434..3729904 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA13_RS17280 (PALA13_03436) 3725302..3726027 - 726 WP_023087304.1 CBASS effector endonuclease NucC -
PALA13_RS17285 (PALA13_03437) 3726064..3726966 - 903 WP_023087303.1 CBASS oligonucleotide cyclase -
PALA13_RS17290 (PALA13_03438) 3726966..3727466 - 501 WP_003050262.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA13_RS17295 (PALA13_03439) 3727463..3727933 - 471 WP_023087302.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA13_RS17300 (PALA13_03440) 3727930..3728844 - 915 WP_023087301.1 AAA family ATPase -
PALA13_RS17305 (PALA13_03441) 3728862..3729437 - 576 WP_003050248.1 PIN domain-containing protein Toxin
PALA13_RS17310 (PALA13_03442) 3729434..3729904 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA13_RS17315 (PALA13_03443) 3730108..3730491 + 384 WP_023087300.1 RAQPRD family integrative conjugative element protein -
PALA13_RS17320 (PALA13_03444) 3730488..3730721 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA13_RS17325 (PALA13_03445) 3730738..3731097 + 360 WP_021195311.1 TIGR03745 family integrating conjugative element membrane protein -
PALA13_RS17330 (PALA13_03446) 3731110..3731508 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA13_RS17335 (PALA13_03447) 3731505..3732197 + 693 WP_023087299.1 TIGR03746 family integrating conjugative element protein -
PALA13_RS17340 (PALA13_03448) 3732194..3733105 + 912 WP_023087298.1 TIGR03749 family integrating conjugative element protein -
PALA13_RS17345 (PALA13_03449) 3733095..3734513 + 1419 WP_023087297.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3683374..3798590 115216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21630.76 Da        Isoelectric Point: 5.6130

>T259649 WP_003050248.1 NZ_CP106682:c3729437-3728862 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT259649 WP_003050245.1 NZ_CP106682:c3729904-3729434 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References