Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2757108..2758329 Replicon chromosome
Accession NZ_CP106682
Organism Pseudomonas aeruginosa strain PALA13

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA13_RS13095 Protein ID WP_003102740.1
Coordinates 2757108..2757686 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA13_RS13100 Protein ID WP_003088112.1
Coordinates 2757775..2758329 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA13_RS13080 (PALA13_02595) 2752384..2753661 + 1278 WP_003102743.1 TolC family protein -
PALA13_RS13085 (PALA13_02596) 2753651..2755822 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA13_RS13090 (PALA13_02597) 2755812..2756999 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA13_RS13095 (PALA13_02598) 2757108..2757686 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA13_RS13100 (PALA13_02599) 2757775..2758329 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA13_RS13105 (PALA13_02600) 2758487..2760682 - 2196 WP_023087567.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA13_RS13110 (PALA13_02601) 2760687..2761148 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA13_RS13115 (PALA13_02602) 2761479..2761802 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA13_RS13120 (PALA13_02603) 2761815..2762213 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA13_RS13125 (PALA13_02604) 2762210..2762761 - 552 WP_016253541.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259648 WP_003102740.1 NZ_CP106682:c2757686-2757108 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259648 WP_003088112.1 NZ_CP106682:c2758329-2757775 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References