Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1833324..1834582 Replicon chromosome
Accession NZ_CP106682
Organism Pseudomonas aeruginosa strain PALA13

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA13_RS08715 Protein ID WP_003112528.1
Coordinates 1833827..1834582 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA13_RS08710 Protein ID WP_003086329.1
Coordinates 1833324..1833692 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA13_RS08690 1829487..1829762 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
PALA13_RS08695 (PALA13_01718) 1829765..1830241 - 477 WP_003112531.1 hypothetical protein -
PALA13_RS08700 (PALA13_01719) 1830320..1831909 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA13_RS08705 (PALA13_01720) 1831965..1833251 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA13_RS08710 (PALA13_01721) 1833324..1833692 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA13_RS08715 (PALA13_01722) 1833827..1834582 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA13_RS08720 (PALA13_01723) 1835350..1836711 + 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA13_RS08725 (PALA13_01724) 1836866..1839409 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T259647 WP_003112528.1 NZ_CP106682:1833827-1834582 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259647 WP_003086329.1 NZ_CP106682:1833324-1833692 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References