Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 3946819..3948514 | Replicon | chromosome |
Accession | NZ_CP106681 | ||
Organism | Pseudomonas aeruginosa strain PALA12 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q9HYA0 |
Locus tag | PALA12_RS18275 | Protein ID | WP_003112901.1 |
Coordinates | 3947645..3948514 (-) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q9HYA1 |
Locus tag | PALA12_RS18270 | Protein ID | WP_003112902.1 |
Coordinates | 3946819..3947652 (-) | Length | 278 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PALA12_RS18250 (PALA12_03610) | 3942050..3943534 | - | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
PALA12_RS18255 (PALA12_03611) | 3943546..3944349 | - | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
PALA12_RS18260 (PALA12_03612) | 3944360..3946042 | - | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
PALA12_RS18265 (PALA12_03613) | 3946035..3946832 | - | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
PALA12_RS18270 (PALA12_03614) | 3946819..3947652 | - | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
PALA12_RS18275 (PALA12_03615) | 3947645..3948514 | - | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
PALA12_RS18280 (PALA12_03616) | 3948523..3949053 | - | 531 | WP_003112900.1 | cupin domain-containing protein | - |
PALA12_RS18285 (PALA12_03617) | 3949067..3949828 | - | 762 | WP_023083383.1 | SDR family oxidoreductase | - |
PALA12_RS18290 (PALA12_03618) | 3949834..3950610 | - | 777 | WP_003112898.1 | ABC transporter permease | - |
PALA12_RS18295 (PALA12_03619) | 3950607..3951614 | - | 1008 | WP_269974038.1 | ABC transporter substrate-binding protein | - |
PALA12_RS18300 (PALA12_03620) | 3951655..3952506 | - | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T259641 WP_003112901.1 NZ_CP106681:c3948514-3947645 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT259641 WP_003112902.1 NZ_CP106681:c3947652-3946819 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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