Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3681954..3683462 Replicon chromosome
Accession NZ_CP106681
Organism Pseudomonas aeruginosa strain PALA12

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA12_RS17035 Protein ID WP_003119682.1
Coordinates 3682875..3683462 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag PALA12_RS17030 Protein ID WP_003119683.1
Coordinates 3681954..3682808 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA12_RS17015 (PALA12_03366) 3677373..3677582 + 210 WP_003115568.1 cold-shock protein -
PALA12_RS17020 (PALA12_03367) 3677643..3679517 - 1875 WP_003117607.1 MFS transporter -
PALA12_RS17025 (PALA12_03368) 3679692..3681857 - 2166 WP_016852624.1 TonB-dependent receptor family protein -
PALA12_RS17030 (PALA12_03369) 3681954..3682808 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
PALA12_RS17035 (PALA12_03370) 3682875..3683462 - 588 WP_003119682.1 GNAT family protein Toxin
PALA12_RS17040 (PALA12_03371) 3683728..3687207 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T259640 WP_003119682.1 NZ_CP106681:c3683462-3682875 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT259640 WP_003119683.1 NZ_CP106681:c3682808-3681954 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References