25964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 4712031..4712547 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag SL1344_RS22830 Protein ID WP_000220578.1
Coordinates 4712263..4712547 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag SL1344_RS22825 Protein ID WP_000212724.1
Coordinates 4712031..4712273 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS22805 (SL1344_4375) 4707051..4708184 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
SL1344_RS22810 (SL1344_4376) 4708168..4709286 + 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
SL1344_RS22815 (SL1344_4377) 4709283..4710023 + 741 WP_000779263.1 KDGP aldolase family protein -
SL1344_RS22820 (SL1344_4378) 4710040..4711953 + 1914 WP_001212137.1 BglG family transcription antiterminator -
SL1344_RS22825 (SL1344_4379) 4712031..4712273 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SL1344_RS22830 (SL1344_4380) 4712263..4712547 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SL1344_RS22835 (SL1344_4381) 4712551..4713015 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
SL1344_RS22840 (SL1344_4382) 4713136..4715274 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
SL1344_RS22850 (SL1344_4384) 4715683..4717335 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T25964 WP_000220578.1 NC_016810:4712263-4712547 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T25964 NC_016810:4712263-4712547 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT25964 WP_000212724.1 NC_016810:4712031-4712273 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT25964 NC_016810:4712031-4712273 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References