259639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2820345..2821387 Replicon chromosome
Accession NZ_CP106681
Organism Pseudomonas aeruginosa strain PALA12

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA12_RS12830 Protein ID WP_003153636.1
Coordinates 2820345..2820920 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA12_RS12835 Protein ID WP_003050245.1
Coordinates 2820917..2821387 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA12_RS12805 (PALA12_02528) 2816783..2817508 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
PALA12_RS12810 (PALA12_02529) 2817547..2818449 - 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PALA12_RS12815 (PALA12_02530) 2818449..2818949 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA12_RS12820 (PALA12_02531) 2818946..2819416 - 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA12_RS12825 (PALA12_02532) 2819413..2820327 - 915 WP_016852809.1 AAA family ATPase -
PALA12_RS12830 (PALA12_02533) 2820345..2820920 - 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA12_RS12835 (PALA12_02534) 2820917..2821387 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA12_RS12840 (PALA12_02535) 2821591..2821974 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA12_RS12845 (PALA12_02536) 2821971..2822204 + 234 WP_006226027.1 TIGR03758 family integrating conjugative element protein -
PALA12_RS12850 (PALA12_02537) 2822221..2822580 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA12_RS12855 (PALA12_02538) 2822592..2822990 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PALA12_RS12860 (PALA12_02539) 2822987..2823679 + 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PALA12_RS12865 (PALA12_02540) 2823676..2824587 + 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PALA12_RS12870 (PALA12_02541) 2824577..2825995 + 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2774229..2895962 121733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T259639 WP_003153636.1 NZ_CP106681:c2820920-2820345 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT259639 WP_003050245.1 NZ_CP106681:c2821387-2820917 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References