Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 1822422..1823643 | Replicon | chromosome |
| Accession | NZ_CP106681 | ||
| Organism | Pseudomonas aeruginosa strain PALA12 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA12_RS08535 | Protein ID | WP_003114949.1 |
| Coordinates | 1822422..1823000 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA12_RS08540 | Protein ID | WP_003088112.1 |
| Coordinates | 1823089..1823643 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA12_RS08520 (PALA12_01698) | 1817699..1818976 | + | 1278 | WP_003102743.1 | TolC family protein | - |
| PALA12_RS08525 (PALA12_01699) | 1818966..1821137 | + | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| PALA12_RS08530 (PALA12_01700) | 1821127..1822314 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA12_RS08535 (PALA12_01701) | 1822422..1823000 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| PALA12_RS08540 (PALA12_01702) | 1823089..1823643 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA12_RS08545 (PALA12_01703) | 1823801..1825996 | - | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA12_RS08550 (PALA12_01704) | 1826001..1826462 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA12_RS08555 (PALA12_01705) | 1826793..1827116 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA12_RS08560 (PALA12_01706) | 1827129..1827527 | + | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA12_RS08565 (PALA12_01707) | 1827524..1828075 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T259638 WP_003114949.1 NZ_CP106681:c1823000-1822422 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT259638 WP_003088112.1 NZ_CP106681:c1823643-1823089 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|