259637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 895380..896638 Replicon chromosome
Accession NZ_CP106681
Organism Pseudomonas aeruginosa strain PALA12

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA12_RS04170 Protein ID WP_003112528.1
Coordinates 895883..896638 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA12_RS04165 Protein ID WP_003086329.1
Coordinates 895380..895748 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA12_RS04145 891543..891818 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
PALA12_RS04150 (PALA12_00825) 891821..892297 - 477 WP_003112531.1 hypothetical protein -
PALA12_RS04155 (PALA12_00826) 892376..893965 + 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA12_RS04160 (PALA12_00827) 894021..895307 + 1287 WP_023083139.1 FAD-binding oxidoreductase -
PALA12_RS04165 (PALA12_00828) 895380..895748 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA12_RS04170 (PALA12_00829) 895883..896638 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA12_RS04175 (PALA12_00830) 897406..898767 + 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA12_RS04180 (PALA12_00831) 898922..901465 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T259637 WP_003112528.1 NZ_CP106681:895883-896638 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259637 WP_003086329.1 NZ_CP106681:895380-895748 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References