259634

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4459202..4460460 Replicon chromosome
Accession NZ_CP106680
Organism Pseudomonas aeruginosa strain PALA11

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA11_RS20705 Protein ID WP_003163133.1
Coordinates 4459202..4459957 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA11_RS20710 Protein ID WP_003086329.1
Coordinates 4460092..4460460 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA11_RS20695 (PALA11_04114) 4454379..4456922 + 2544 WP_003120631.1 acyl-homoserine-lactone acylase QuiP -
PALA11_RS20700 (PALA11_04115) 4457078..4458439 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA11_RS20705 (PALA11_04116) 4459202..4459957 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA11_RS20710 (PALA11_04117) 4460092..4460460 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA11_RS20715 (PALA11_04118) 4460533..4461819 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PALA11_RS20720 (PALA11_04119) 4461875..4463464 - 1590 WP_078452049.1 aldehyde dehydrogenase family protein -
PALA11_RS20725 (PALA11_04120) 4463543..4464019 + 477 WP_003112531.1 hypothetical protein -
PALA11_RS20730 4464022..4464297 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T259634 WP_003163133.1 NZ_CP106680:c4459957-4459202 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259634 WP_003086329.1 NZ_CP106680:c4460460-4460092 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References