Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/- |
| Location | 4583140..4583921 | Replicon | |
| Accession | NC_016810 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | SL1344_RS22165 | Protein ID | WP_000626099.1 |
| Coordinates | 4583430..4583921 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | SL1344_RS22160 | Protein ID | WP_001110452.1 |
| Coordinates | 4583140..4583433 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SL1344_RS22130 (SL1344_4247) | 4579464..4580369 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| SL1344_RS22135 (SL1344_4248) | 4580663..4580932 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| SL1344_RS26870 (SL1344_4249) | 4580940..4581155 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| SL1344_RS22145 (SL1344_4250) | 4581178..4581465 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| SL1344_RS22150 (SL1344_4251) | 4581462..4582337 | - | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| SL1344_RS22155 (SL1344_4252) | 4582602..4582823 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| SL1344_RS22160 (SL1344_4253) | 4583140..4583433 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| SL1344_RS22165 (SL1344_4254) | 4583430..4583921 | + | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| SL1344_RS22170 (SL1344_4255) | 4584169..4584921 | - | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| SL1344_RS27785 | 4585024..4585098 | - | 75 | Protein_4349 | porin family protein | - |
| SL1344_RS22175 (SL1344_4257) | 4586131..4586508 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| SL1344_RS22180 (SL1344_4258) | 4586580..4586912 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| SL1344_RS26205 | 4587003..4587080 | + | 78 | Protein_4352 | helix-turn-helix domain-containing protein | - |
| SL1344_RS22190 (SL1344_4259) | 4587351..4587926 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T25963 WP_000626099.1 NC_016810:4583430-4583921 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T25963 NC_016810:4583430-4583921 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT25963 WP_001110452.1 NC_016810:4583140-4583433 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT25963 NC_016810:4583140-4583433 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |