Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2297048..2298026 Replicon chromosome
Accession NZ_CP106675
Organism Bacillus cereus strain SRCM116293

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag N7988_RS11860 Protein ID WP_000624977.1
Coordinates 2297048..2297785 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag N7988_RS11865 Protein ID WP_000237818.1
Coordinates 2297898..2298026 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7988_RS11835 (N7988_11835) 2292664..2293071 + 408 WP_000063589.1 VOC family protein -
N7988_RS11840 (N7988_11840) 2293084..2293473 + 390 Protein_2248 SAM-dependent methyltransferase -
N7988_RS11845 (N7988_11845) 2293631..2295316 - 1686 WP_058839616.1 alpha-keto acid decarboxylase family protein -
N7988_RS11850 (N7988_11850) 2295424..2295906 + 483 WP_098348562.1 MarR family winged helix-turn-helix transcriptional regulator -
N7988_RS11855 (N7988_11855) 2296073..2296810 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
N7988_RS11860 (N7988_11860) 2297048..2297785 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
N7988_RS11865 (N7988_11865) 2297898..2298026 + 129 WP_000237818.1 hypothetical protein Antitoxin
N7988_RS11870 (N7988_11870) 2298099..2298275 + 177 WP_000852629.1 stage II sporulation protein SB -
N7988_RS11875 (N7988_11875) 2298294..2298683 - 390 WP_098348563.1 YxeA family protein -
N7988_RS11880 (N7988_11880) 2298895..2300364 + 1470 WP_065704141.1 beta-Ala-His dipeptidase -
N7988_RS11885 (N7988_11885) 2300610..2301419 + 810 WP_000678509.1 papain-like cysteine protease family protein -
N7988_RS11890 (N7988_11890) 2301445..2302047 + 603 WP_000517260.1 hypothetical protein -
N7988_RS11895 (N7988_11895) 2302288..2302539 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T259629 WP_000624977.1 NZ_CP106675:2297048-2297785 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT259629 WP_000237818.1 NZ_CP106675:2297898-2298026 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References