Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 230768..231410 Replicon chromosome
Accession NZ_CP106675
Organism Bacillus cereus strain SRCM116293

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag N7988_RS01325 Protein ID WP_000635965.1
Coordinates 231060..231410 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag N7988_RS01320 Protein ID WP_000004570.1
Coordinates 230768..231055 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7988_RS01295 (N7988_01295) 226085..227047 + 963 WP_098347994.1 UV DNA damage repair endonuclease UvsE -
N7988_RS01300 (N7988_01300) 227040..227612 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
N7988_RS01305 (N7988_01305) 227706..228065 + 360 WP_000583417.1 holo-ACP synthase -
N7988_RS01310 (N7988_01310) 228222..229172 + 951 WP_002060618.1 outer membrane lipoprotein carrier protein LolA -
N7988_RS01315 (N7988_01315) 229290..230459 + 1170 WP_262314141.1 alanine racemase -
N7988_RS01320 (N7988_01320) 230768..231055 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
N7988_RS01325 (N7988_01325) 231060..231410 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
N7988_RS01330 (N7988_01330) 231478..233646 + 2169 WP_142320223.1 Tex family protein -
N7988_RS01335 (N7988_01335) 233704..233820 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
N7988_RS01340 (N7988_01340) 234016..234474 + 459 WP_000344241.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T259628 WP_000635965.1 NZ_CP106675:231060-231410 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT259628 WP_000004570.1 NZ_CP106675:230768-231055 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References