Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 56242..56764 Replicon plasmid pSG.G2
Accession NZ_CP106664
Organism Brucella intermedia strain SG.G2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N8I72_RS22080 Protein ID WP_182506626.1
Coordinates 56242..56529 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A6X7N0
Locus tag N8I72_RS22085 Protein ID WP_011982865.1
Coordinates 56519..56764 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I72_RS22055 (N8I72_22060) 51965..52978 + 1014 WP_182506622.1 zinc-binding dehydrogenase -
N8I72_RS22060 (N8I72_22065) 53037..53921 + 885 WP_182506623.1 hypothetical protein -
N8I72_RS22065 (N8I72_22070) 54182..54307 + 126 Protein_59 IS6 family transposase -
N8I72_RS22070 (N8I72_22075) 54529..55083 + 555 Protein_60 cell filamentation protein Fic -
N8I72_RS22075 (N8I72_22080) 55297..56184 + 888 WP_182506625.1 zincin-like metallopeptidase domain-containing protein -
N8I72_RS22080 (N8I72_22085) 56242..56529 - 288 WP_182506626.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I72_RS22085 (N8I72_22090) 56519..56764 - 246 WP_011982865.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N8I72_RS22090 (N8I72_22095) 56925..57413 - 489 WP_049768461.1 helix-turn-helix transcriptional regulator -
N8I72_RS22095 (N8I72_22100) 57593..57970 - 378 WP_138787172.1 hypothetical protein -
N8I72_RS22100 (N8I72_22105) 57973..58398 - 426 WP_262077897.1 hypothetical protein -
N8I72_RS22105 (N8I72_22110) 58391..59087 - 697 Protein_67 ParA family protein -
N8I72_RS22110 (N8I72_22115) 59401..59883 + 483 WP_262077914.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..176207 176207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11012.83 Da        Isoelectric Point: 10.6834

>T259615 WP_182506626.1 NZ_CP106664:c56529-56242 [Brucella intermedia]
MPYKLEFLPSALKEWNKLGATIQQQLKKKLRERLETPRVVSASLHGMPDHYKIKLRQLGYRLVYSVNDDTVTVLVIAVGK
RERGDVYNTARTRSQ

Download         Length: 288 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8886.16 Da        Isoelectric Point: 4.2813

>AT259615 WP_011982865.1 NZ_CP106664:c56764-56519 [Brucella intermedia]
MQRVEANIAVSVSDLKKSPSAVMDEANGEAVAVLNHNRIMAYMVPAGVYEAMLEQLDDIRLTEIIRNRADEKGISVDIDA
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6X7N0

References