Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4042503..4044070 Replicon chromosome
Accession NZ_CP106660
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N7977_RS18915 Protein ID WP_262256721.1
Coordinates 4042503..4043813 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N7977_RS18920 Protein ID WP_104094318.1
Coordinates 4043813..4044070 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS18890 (N7977_18890) 4037999..4038661 - 663 WP_058758205.1 6-phosphogluconate phosphatase -
N7977_RS18895 (N7977_18895) 4038813..4040126 + 1314 WP_058770726.1 NCS2 family permease -
N7977_RS18900 (N7977_18900) 4040154..4040918 - 765 WP_058775620.1 hypothetical protein -
N7977_RS18905 (N7977_18905) 4041212..4041721 + 510 WP_031279601.1 flavin reductase family protein -
N7977_RS18910 (N7977_18910) 4041763..4042353 - 591 WP_021506918.1 malonic semialdehyde reductase -
N7977_RS18915 (N7977_18915) 4042503..4043813 - 1311 WP_262256721.1 type II toxin-antitoxin system HipA family toxin Toxin
N7977_RS18920 (N7977_18920) 4043813..4044070 - 258 WP_104094318.1 helix-turn-helix domain-containing protein Antitoxin
N7977_RS18925 (N7977_18925) 4044276..4045640 - 1365 WP_262256723.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
N7977_RS18930 (N7977_18930) 4045721..4047367 - 1647 WP_021506916.1 membrane protein insertase YidC -
N7977_RS18935 (N7977_18935) 4047370..4047627 - 258 WP_071813586.1 membrane protein insertion efficiency factor YidD -
N7977_RS18940 (N7977_18940) 4047591..4047950 - 360 WP_040679622.1 ribonuclease P protein component -
N7977_RS18945 (N7977_18945) 4047966..4048106 - 141 WP_000831330.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49002.10 Da        Isoelectric Point: 8.4349

>T259610 WP_262256721.1 NZ_CP106660:c4043813-4042503 [Pantoea dispersa]
MTELDVYMNGYRTGVFSRAATGAHTFRYYESWLNQPGSRPISLSMPLRHQPYKGAEVYNFFDNLLPDNPEIRARILSRYQ
ASSTQPFDLLAKVGSDTIGALQLLPPDSKPHTVRTIDYRRLSDSELEKILSGYQSGAPLGMLEELTDFRISLAGAQEKTA
LLRIDQQWCLPQGNTPTTHILKLPIGNIQSHSHRIDLSDSVENEWLCTLIAREFGLAVPSCFIVNTGKIKALAVERFDRR
YASDGQWIMRLPQEDFCQVLNVPAAGKYESHGGPGISAIMDYLLNSVNAEQDRYDFMKAQVLFWLLAATDGHAKNFSIFI
EAEGRFRLTPFYDILSVYPVIGGAGLHIRDVKLAMGLNGSKGRKAAIEHIFPRHFIETAKTTKFALTAMAHILDEFRART
PEVIQRVQEQIPAAFPLRVSQTILNGFKARAARLQQ

Download         Length: 1311 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9693.11 Da        Isoelectric Point: 8.5776

>AT259610 WP_104094318.1 NZ_CP106660:c4044070-4043813 [Pantoea dispersa]
MKITSAKQLSSYLKDRRLTESLSQAKVASKIGIRQDTVSSFELQPETTRLDTLFRILAALDLEMEIKPRGLPSAKQDPDG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References