Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3601185..3601884 Replicon chromosome
Accession NZ_CP106660
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N7977_RS16920 Protein ID WP_072208527.1
Coordinates 3601708..3601884 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N7977_RS16915 Protein ID WP_058757543.1
Coordinates 3601185..3601589 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS16900 (N7977_16900) 3598354..3598593 + 240 WP_262256515.1 hypothetical protein -
N7977_RS16905 (N7977_16905) 3598688..3600127 - 1440 WP_262258106.1 PTS N-acetylmuramic acid transporter subunit IIBC -
N7977_RS16910 (N7977_16910) 3600127..3601038 - 912 WP_262256517.1 N-acetylmuramic acid 6-phosphate etherase -
N7977_RS16915 (N7977_16915) 3601185..3601589 - 405 WP_058757543.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N7977_RS16920 (N7977_16920) 3601708..3601884 - 177 WP_072208527.1 type II toxin-antitoxin system HicA family toxin Toxin
N7977_RS16925 (N7977_16925) 3602060..3603361 - 1302 WP_021507820.1 glutamate/aspartate:proton symporter GltP -
N7977_RS16930 (N7977_16930) 3603942..3605897 + 1956 WP_058774926.1 acetate--CoA ligase -
N7977_RS16935 (N7977_16935) 3606071..3606400 + 330 WP_021313201.1 DUF485 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6824.11 Da        Isoelectric Point: 10.6691

>T259609 WP_072208527.1 NZ_CP106660:c3601884-3601708 [Pantoea dispersa]
MSSRELIRMLLERGWILDRVKGSHHVFVRADKPYHISLPHPEKDLATGTLRKLLKMMD

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14655.39 Da        Isoelectric Point: 4.9322

>AT259609 WP_058757543.1 NZ_CP106660:c3601589-3601185 [Pantoea dispersa]
MRFPVYLHKTENGSWSGFVPDVQGCFFAGNTVDEALSDAFGAIDAHVESLADAGKAIPKAASVETHINDEECQGGYWAFV
EIDLSRYEGKAVKLNITLPQNLLTKIDSHVEAHREYGSRSGFLAALARRELANI

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References