Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 75743..76653 | Replicon | plasmid p8BG |
| Accession | NZ_CP106659 | ||
| Organism | Klebsiella michiganensis strain 8BG | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | N7918_RS29095 | Protein ID | WP_004026354.1 |
| Coordinates | 75743..76213 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | N7918_RS29100 | Protein ID | WP_004181895.1 |
| Coordinates | 76210..76653 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N7918_RS29075 (N7918_29075) | 70954..71832 | + | 879 | WP_262191644.1 | LysR family transcriptional regulator | - |
| N7918_RS29085 (N7918_29085) | 74227..74487 | + | 261 | WP_032719456.1 | hypothetical protein | - |
| N7918_RS29090 (N7918_29090) | 75100..75288 | + | 189 | WP_024198076.1 | hypothetical protein | - |
| N7918_RS29095 (N7918_29095) | 75743..76213 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| N7918_RS29100 (N7918_29100) | 76210..76653 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| N7918_RS29105 (N7918_29105) | 76754..77950 | - | 1197 | WP_262191650.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| N7918_RS29110 (N7918_29110) | 78315..78699 | + | 385 | Protein_85 | IS3 family transposase | - |
| N7918_RS29115 (N7918_29115) | 78878..79927 | - | 1050 | WP_004883371.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| N7918_RS29120 (N7918_29120) | 79938..80597 | - | 660 | WP_004883369.1 | DUF6088 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..168116 | 168116 | |
| - | flank | IS/Tn | - | - | 72163..72966 | 803 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T259603 WP_004026354.1 NZ_CP106659:c76213-75743 [Klebsiella michiganensis]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT259603 WP_004181895.1 NZ_CP106659:c76653-76210 [Klebsiella michiganensis]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |