Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 66120..66859 Replicon plasmid p8BG
Accession NZ_CP106659
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag N7918_RS29045 Protein ID WP_262191639.1
Coordinates 66120..66605 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag N7918_RS29050 Protein ID WP_262191640.1
Coordinates 66593..66859 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS29025 (N7918_29025) 61710..62777 - 1068 WP_262191637.1 hypothetical protein -
N7918_RS29030 (N7918_29030) 63467..63844 + 378 WP_262191638.1 phosphonate ABC transporter substrate-binding protein -
N7918_RS29035 (N7918_29035) 64042..65016 - 975 WP_064794367.1 hypothetical protein -
N7918_RS29040 (N7918_29040) 65619..65777 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
N7918_RS29045 (N7918_29045) 66120..66605 - 486 WP_262191639.1 GNAT family N-acetyltransferase Toxin
N7918_RS29050 (N7918_29050) 66593..66859 - 267 WP_262191640.1 DUF1778 domain-containing protein Antitoxin
N7918_RS29055 (N7918_29055) 67015..68403 - 1389 WP_262191641.1 MFS transporter -
N7918_RS29060 (N7918_29060) 68642..69043 + 402 WP_024140008.1 MarR family winged helix-turn-helix transcriptional regulator -
N7918_RS29065 (N7918_29065) 69154..70164 + 1011 WP_262191642.1 aldo/keto reductase -
N7918_RS29070 (N7918_29070) 70263..70850 - 588 WP_262191649.1 cysteine/O-acetylserine transporter -
N7918_RS29075 (N7918_29075) 70954..71832 + 879 WP_262191644.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..168116 168116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17708.47 Da        Isoelectric Point: 9.8719

>T259602 WP_262191639.1 NZ_CP106659:c66605-66120 [Klebsiella michiganensis]
VGHVTAPEPLSAFHQVAEFVSGETVLDDWLKQKGLKNQSLGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10078.55 Da        Isoelectric Point: 4.4733

>AT259602 WP_262191640.1 NZ_CP106659:c66859-66593 [Klebsiella michiganensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPVIGKLL
ARKPQWDM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References