Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5326781..5327553 Replicon chromosome
Accession NZ_CP106658
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag N7918_RS25220 Protein ID WP_047935068.1
Coordinates 5326781..5327170 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N7918_RS25225 Protein ID WP_171820356.1
Coordinates 5327227..5327553 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS25195 (N7918_25195) 5323077..5323445 - 369 WP_224255022.1 hypothetical protein -
N7918_RS25200 (N7918_25200) 5323842..5324441 - 600 WP_257393814.1 transcriptional regulator -
N7918_RS25205 (N7918_25205) 5324534..5325502 + 969 WP_000654811.1 IS5 family transposase -
N7918_RS25210 (N7918_25210) 5325558..5325704 - 147 Protein_4955 helix-turn-helix transcriptional regulator -
N7918_RS25215 (N7918_25215) 5325848..5326693 - 846 WP_047935067.1 DUF4942 domain-containing protein -
N7918_RS25220 (N7918_25220) 5326781..5327170 - 390 WP_047935068.1 TA system toxin CbtA family protein Toxin
N7918_RS25225 (N7918_25225) 5327227..5327553 - 327 WP_171820356.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7918_RS25230 (N7918_25230) 5327611..5327832 - 222 WP_047724679.1 DUF987 domain-containing protein -
N7918_RS25235 (N7918_25235) 5327846..5328325 - 480 WP_047935070.1 DNA repair protein RadC -
N7918_RS25240 (N7918_25240) 5328337..5328786 - 450 WP_262190908.1 antirestriction protein -
N7918_RS25245 (N7918_25245) 5328819..5329640 - 822 WP_047935072.1 DUF932 domain-containing protein -
N7918_RS25250 (N7918_25250) 5330724..5330969 + 246 Protein_4963 IS66 family insertion sequence element accessory protein TnpB -
N7918_RS25255 (N7918_25255) 5331338..5332075 + 738 WP_047935074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5314530..5372205 57675
- flank IS/Tn - - 5324579..5325502 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14515.62 Da        Isoelectric Point: 9.5224

>T259601 WP_047935068.1 NZ_CP106658:c5327170-5326781 [Klebsiella michiganensis]
MQTKSSPLMREASSRPSPVDVWQALLTCLLAHHYGLTLNDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SIREQSPFITAIDILRARKATGLMNRGTYKEVTAITRGQYPQARISGKR

Download         Length: 390 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12146.79 Da        Isoelectric Point: 6.3163

>AT259601 WP_171820356.1 NZ_CP106658:c5327553-5327227 [Klebsiella michiganensis]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHGVTLYA
KGLTCEADTLGSHGYVYIAIYPAPVTTE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References