Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 5261732..5262308 Replicon chromosome
Accession NZ_CP106658
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag N7918_RS24915 Protein ID WP_038424021.1
Coordinates 5262021..5262308 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0H3H591
Locus tag N7918_RS24910 Protein ID WP_014227757.1
Coordinates 5261732..5262034 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS24895 (N7918_24895) 5258572..5258907 + 336 WP_032719937.1 endoribonuclease SymE -
N7918_RS24900 (N7918_24900) 5259359..5260270 + 912 WP_032693024.1 acetamidase/formamidase family protein -
N7918_RS24905 (N7918_24905) 5260267..5261610 + 1344 WP_148849614.1 APC family permease -
N7918_RS24910 (N7918_24910) 5261732..5262034 - 303 WP_014227757.1 BrnA antitoxin family protein Antitoxin
N7918_RS24915 (N7918_24915) 5262021..5262308 - 288 WP_038424021.1 BrnT family toxin Toxin
N7918_RS24920 (N7918_24920) 5262559..5263002 - 444 WP_014837312.1 FosA family fosfomycin resistance glutathione transferase -
N7918_RS24925 (N7918_24925) 5262996..5263904 - 909 WP_119834582.1 LysR family transcriptional regulator -
N7918_RS24930 (N7918_24930) 5263992..5264774 + 783 WP_014837310.1 NAD(P)H-dependent oxidoreductase -
N7918_RS24935 (N7918_24935) 5264922..5265506 + 585 WP_004098242.1 TetR/AcrR family transcriptional regulator -
N7918_RS24940 (N7918_24940) 5265652..5266452 + 801 WP_046878031.1 winged helix-turn-helix domain-containing protein -
N7918_RS24945 (N7918_24945) 5266449..5266967 + 519 WP_042944214.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11253.72 Da        Isoelectric Point: 8.5899

>T259600 WP_038424021.1 NZ_CP106658:c5262308-5262021 [Klebsiella michiganensis]
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTLGLVHGIIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11607.18 Da        Isoelectric Point: 9.4429

>AT259600 WP_014227757.1 NZ_CP106658:c5262034-5261732 [Klebsiella michiganensis]
MNMVKHKRDNPDTLTAKRDDELKALANKTDDEIDYSDIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H591

References