25960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 3859051..3859811 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag SL1344_RS18820 Protein ID WP_000533909.1
Coordinates 3859051..3859536 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag SL1344_RS18825 Protein ID WP_000965886.1
Coordinates 3859524..3859811 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS18790 (SL1344_3611) 3854121..3854783 + 663 WP_000747548.1 OmpA family lipoprotein -
SL1344_RS18795 (SL1344_3612) 3855002..3855976 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
SL1344_RS18800 (SL1344_3613) 3856026..3856736 - 711 WP_000190524.1 DUF3053 domain-containing protein -
SL1344_RS18805 (SL1344_3614) 3857175..3857465 + 291 WP_000455790.1 HTH-type transcriptional regulator -
SL1344_RS18810 (SL1344_3615) 3857754..3857966 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
SL1344_RS18815 (SL1344_3616) 3858140..3858679 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
SL1344_RS18820 (SL1344_3617) 3859051..3859536 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
SL1344_RS18825 (SL1344_3618) 3859524..3859811 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
SL1344_RS18830 (SL1344_3619) 3859989..3860456 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
SL1344_RS26830 3860628..3860903 - 276 Protein_3708 IS3 family transposase -
SL1344_RS18835 (SL1344_3620) 3861085..3863154 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
SL1344_RS18840 (SL1344_3621) 3863164..3864075 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
SL1344_RS18845 (SL1344_3622) 3864214..3864516 - 303 WP_000605588.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T25960 WP_000533909.1 NC_016810:c3859536-3859051 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T25960 NC_016810:c3859536-3859051 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT25960 WP_000965886.1 NC_016810:c3859811-3859524 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT25960 NC_016810:c3859811-3859524 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References