259599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4803492..4804311 Replicon chromosome
Accession NZ_CP106658
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag N7918_RS22840 Protein ID WP_004110819.1
Coordinates 4804054..4804311 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag N7918_RS22835 Protein ID WP_014837489.1
Coordinates 4803492..4804043 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS22805 (N7918_22805) 4799416..4800189 + 774 WP_088168442.1 Zygote formation protein zyg1 -
N7918_RS22810 (N7918_22810) 4800500..4800973 + 474 WP_032693194.1 hypothetical protein -
N7918_RS22815 (N7918_22815) 4801242..4801591 - 350 Protein_4490 type II toxin-antitoxin system VapC family toxin -
N7918_RS22820 (N7918_22820) 4801654..4801812 - 159 Protein_4491 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
N7918_RS22825 (N7918_22825) 4801846..4802592 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
N7918_RS22830 (N7918_22830) 4803016..4803378 - 363 Protein_4493 class I SAM-dependent methyltransferase -
N7918_RS22835 (N7918_22835) 4803492..4804043 - 552 WP_014837489.1 N-acetyltransferase Antitoxin
N7918_RS22840 (N7918_22840) 4804054..4804311 - 258 WP_004110819.1 YjhX family toxin Toxin
N7918_RS22845 (N7918_22845) 4804987..4806171 + 1185 WP_014228054.1 mannonate dehydratase -
N7918_RS22850 (N7918_22850) 4806245..4807720 + 1476 WP_014228053.1 fructuronate reductase -
N7918_RS22855 (N7918_22855) 4807859..4808635 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T259599 WP_004110819.1 NZ_CP106658:c4804311-4804054 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19902.64 Da        Isoelectric Point: 6.4913

>AT259599 WP_014837489.1 NZ_CP106658:c4804043-4803492 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References