Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 955116..955773 Replicon chromosome
Accession NZ_CP106658
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag N7918_RS04670 Protein ID WP_004854060.1
Coordinates 955363..955773 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag N7918_RS04665 Protein ID WP_004124953.1
Coordinates 955116..955382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS04650 (N7918_04650) 950350..950775 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
N7918_RS04655 (N7918_04655) 950896..953694 - 2799 WP_032720094.1 transcriptional regulator DagR -
N7918_RS04660 (N7918_04660) 953888..954871 - 984 WP_262191091.1 tRNA-modifying protein YgfZ -
N7918_RS04665 (N7918_04665) 955116..955382 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
N7918_RS04670 (N7918_04670) 955363..955773 + 411 WP_004854060.1 protein YgfX Toxin
N7918_RS04675 (N7918_04675) 955782..956303 - 522 WP_014226792.1 flavodoxin FldB -
N7918_RS04680 (N7918_04680) 956425..957321 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
N7918_RS04685 (N7918_04685) 957344..958057 + 714 WP_262191092.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7918_RS04690 (N7918_04690) 958063..959796 + 1734 WP_262191093.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T259592 WP_004854060.1 NZ_CP106658:955363-955773 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT259592 WP_004124953.1 NZ_CP106658:955116-955382 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References