Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 794329..795098 Replicon chromosome
Accession NZ_CP106658
Organism Klebsiella michiganensis strain 8BG

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag N7918_RS03840 Protein ID WP_114262886.1
Coordinates 794329..794715 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N7918_RS03845 Protein ID WP_171820356.1
Coordinates 794772..795098 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7918_RS03825 (N7918_03825) 789726..791096 - 1371 WP_014839553.1 cystathionine beta-synthase -
N7918_RS03830 (N7918_03830) 791642..793030 + 1389 WP_042946044.1 DASS family sodium-coupled anion symporter -
N7918_RS03835 (N7918_03835) 793882..794242 - 361 Protein_754 DUF4942 domain-containing protein -
N7918_RS03840 (N7918_03840) 794329..794715 - 387 WP_114262886.1 TA system toxin CbtA family protein Toxin
N7918_RS03845 (N7918_03845) 794772..795098 - 327 WP_171820356.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7918_RS03850 (N7918_03850) 795156..795377 - 222 WP_004192297.1 DUF987 domain-containing protein -
N7918_RS03855 (N7918_03855) 795391..795870 - 480 WP_257945973.1 DNA repair protein RadC -
N7918_RS03860 (N7918_03860) 795882..796325 - 444 WP_114262889.1 antirestriction protein -
N7918_RS03865 (N7918_03865) 796405..796635 - 231 WP_224357616.1 DUF905 domain-containing protein -
N7918_RS03870 (N7918_03870) 796659..797483 - 825 WP_114262890.1 DUF932 domain-containing protein -
N7918_RS03875 (N7918_03875) 798006..798638 + 633 WP_072024984.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-110)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14405.54 Da        Isoelectric Point: 8.0783

>T259591 WP_114262886.1 NZ_CP106658:c794715-794329 [Klebsiella michiganensis]
MQTKLPFMRAASSRPSPVDVWQTLLTCLLEHHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGFS
ILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Download         Length: 387 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12146.79 Da        Isoelectric Point: 6.3163

>AT259591 WP_171820356.1 NZ_CP106658:c795098-794772 [Klebsiella michiganensis]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHGVTLYA
KGLTCEADTLGSHGYVYIAIYPAPVTTE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References