Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5202424..5203049 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag N7990_RS25585 Protein ID WP_004187928.1
Coordinates 5202424..5202807 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N7990_RS25590 Protein ID WP_004150355.1
Coordinates 5202807..5203049 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS25570 (5199790) 5199790..5200692 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
N7990_RS25575 (5200689) 5200689..5201324 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N7990_RS25580 (5201321) 5201321..5202250 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N7990_RS25585 (5202424) 5202424..5202807 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
N7990_RS25590 (5202807) 5202807..5203049 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N7990_RS25595 (5203243) 5203243..5204160 + 918 WP_004187929.1 alpha/beta hydrolase -
N7990_RS25600 (5204174) 5204174..5205115 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N7990_RS25605 (5205160) 5205160..5205597 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N7990_RS25610 (5205594) 5205594..5206454 - 861 WP_004146232.1 virulence factor BrkB family protein -
N7990_RS25615 (5206448) 5206448..5207047 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T259584 WP_004187928.1 NZ_CP106654:c5202807-5202424 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT259584 WP_004150355.1 NZ_CP106654:c5203049-5202807 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References