Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4880085..4881766 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag N7990_RS24100 Protein ID WP_023328808.1
Coordinates 4880085..4881002 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A486Q3T7
Locus tag N7990_RS24105 Protein ID WP_023328807.1
Coordinates 4881008..4881766 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS24080 (4875391) 4875391..4876911 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
N7990_RS24085 (4876908) 4876908..4877906 + 999 WP_002885172.1 ribose ABC transporter permease -
N7990_RS24090 (4877937) 4877937..4878878 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
N7990_RS24095 (4878953) 4878953..4879960 + 1008 WP_023328809.1 carbohydrate kinase family protein -
N7990_RS24100 (4880085) 4880085..4881002 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N7990_RS24105 (4881008) 4881008..4881766 - 759 WP_023328807.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
N7990_RS24110 (4881852) 4881852..4882580 - 729 WP_002885152.1 response regulator transcription factor -
N7990_RS24115 (4882853) 4882853..4885000 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
N7990_RS24120 (4885230) 4885230..4885916 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T259583 WP_023328808.1 NZ_CP106654:c4881002-4880085 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT259583 WP_023328807.1 NZ_CP106654:c4881766-4881008 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTFSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A0A486Q3T7

References