Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4716061..4716577 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N7990_RS23270 Protein ID WP_002886902.1
Coordinates 4716061..4716345 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N7990_RS23275 Protein ID WP_002886901.1
Coordinates 4716335..4716577 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS23245 (4711545) 4711545..4711808 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
N7990_RS23250 (4711938) 4711938..4712111 + 174 WP_019725541.1 hypothetical protein -
N7990_RS23255 (4712114) 4712114..4712857 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N7990_RS23260 (4713214) 4713214..4715352 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N7990_RS23265 (4715593) 4715593..4716057 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N7990_RS23270 (4716061) 4716061..4716345 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7990_RS23275 (4716335) 4716335..4716577 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7990_RS23280 (4716655) 4716655..4718565 - 1911 WP_023328821.1 PRD domain-containing protein -
N7990_RS23285 (4718588) 4718588..4719742 - 1155 WP_002886900.1 lactonase family protein -
N7990_RS23290 (4719809) 4719809..4720549 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T259582 WP_002886902.1 NZ_CP106654:c4716345-4716061 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT259582 WP_002886901.1 NZ_CP106654:c4716577-4716335 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References