Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4625589..4626277 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag N7990_RS22865 Protein ID WP_023328858.1
Coordinates 4625589..4625930 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N7990_RS22870 Protein ID WP_023328857.1
Coordinates 4625951..4626277 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS22835 (4620611) 4620611..4620877 + 267 WP_004178415.1 hypothetical protein -
N7990_RS22840 (4620877) 4620877..4621549 + 673 Protein_4475 DUF4400 domain-containing protein -
N7990_RS22845 (4621560) 4621560..4622444 + 885 WP_004192285.1 RES domain-containing protein -
N7990_RS22850 (4622643) 4622643..4622831 - 189 Protein_4477 transposase -
N7990_RS22855 (4622848) 4622848..4623959 - 1112 Protein_4478 IS3 family transposase -
N7990_RS22860 (4624327) 4624327..4625334 - 1008 WP_023328859.1 restriction endonuclease -
N7990_RS22865 (4625589) 4625589..4625930 - 342 WP_023328858.1 TA system toxin CbtA family protein Toxin
N7990_RS22870 (4625951) 4625951..4626277 - 327 WP_023328857.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7990_RS22875 (4626291) 4626291..4626767 - 477 WP_262287978.1 DNA repair protein RadC -
N7990_RS22880 (4626778) 4626778..4627218 - 441 WP_023328855.1 antirestriction protein -
N7990_RS22885 (4627288) 4627288..4627518 - 231 WP_023328854.1 DUF905 domain-containing protein -
N7990_RS22890 (4627542) 4627542..4628369 - 828 WP_032430976.1 DUF932 domain-containing protein -
N7990_RS22895 (4628465) 4628465..4629142 - 678 WP_023328852.1 hypothetical protein -
N7990_RS22900 (4629428) 4629428..4630321 - 894 WP_023328851.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4614722..4659495 44773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12806.78 Da        Isoelectric Point: 9.8952

>T259581 WP_023328858.1 NZ_CP106654:c4625930-4625589 [Klebsiella pneumoniae]
MKTLPATTPQAAKLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12320.00 Da        Isoelectric Point: 6.9461

>AT259581 WP_023328857.1 NZ_CP106654:c4626277-4625951 [Klebsiella pneumoniae]
MSSNDLQQWGLCRSISPCFGARLVQERNRLHFLADRAGFNGQFTEEQALRLDQAFPLIMKQLELMLSTGELNPRHSHCVT
LYHNGLTCEADTLGSYGYVYIAVYPTHR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References