Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809964..810621 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N7990_RS04015 Protein ID WP_002916310.1
Coordinates 810211..810621 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N7990_RS04010 Protein ID WP_002916312.1
Coordinates 809964..810230 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS03985 (805120) 805120..806553 - 1434 WP_023328360.1 6-phospho-beta-glucosidase BglA -
N7990_RS03990 (806672) 806672..807400 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N7990_RS03995 (807450) 807450..807761 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N7990_RS04000 (807925) 807925..808584 + 660 WP_002916317.1 hemolysin III family protein -
N7990_RS04005 (808735) 808735..809718 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
N7990_RS04010 (809964) 809964..810230 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N7990_RS04015 (810211) 810211..810621 + 411 WP_002916310.1 protein YgfX Toxin
N7990_RS04020 (810628) 810628..811149 - 522 WP_004144730.1 flavodoxin FldB -
N7990_RS04025 (811250) 811250..812146 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N7990_RS04030 (812169) 812169..812882 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7990_RS04035 (812888) 812888..814621 + 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T259573 WP_002916310.1 NZ_CP106654:810211-810621 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT259573 WP_002916312.1 NZ_CP106654:809964-810230 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References