Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3226728..3227388 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag SL1344_RS15755 Protein ID WP_000244756.1
Coordinates 3226728..3227141 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag SL1344_RS15760 Protein ID WP_000351186.1
Coordinates 3227122..3227388 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS15735 (SL1344_3018) 3222669..3224402 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
SL1344_RS15740 (SL1344_3019) 3224408..3225121 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SL1344_RS15745 (SL1344_3020) 3225145..3226041 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
SL1344_RS15750 (SL1344_3021) 3226154..3226675 + 522 WP_001055885.1 flavodoxin FldB -
SL1344_RS15755 (SL1344_3022) 3226728..3227141 - 414 WP_000244756.1 protein YgfX Toxin
SL1344_RS15760 (SL1344_3023) 3227122..3227388 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
SL1344_RS15770 (SL1344_3024) 3227638..3228618 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
SL1344_RS15775 (SL1344_3025) 3228734..3229393 - 660 WP_000250289.1 hemolysin III family protein -
SL1344_RS15780 (SL1344_3026) 3229557..3229868 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
SL1344_RS15785 (SL1344_3027) 3230027..3231460 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T25957 WP_000244756.1 NC_016810:c3227141-3226728 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T25957 NC_016810:c3227141-3226728 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT25957 WP_000351186.1 NC_016810:c3227388-3227122 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT25957 NC_016810:c3227388-3227122 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References