259569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 525914..526550 Replicon chromosome
Accession NZ_CP106652
Organism Bacillus safensis strain 33.4

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag N7921_RS02545 Protein ID WP_024425388.1
Coordinates 526200..526550 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag N7921_RS02540 Protein ID WP_003214273.1
Coordinates 525914..526195 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7921_RS02520 (N7921_02520) 522072..522677 - 606 WP_144472946.1 rhomboid family intramembrane serine protease -
N7921_RS02525 (N7921_02525) 522772..523137 + 366 WP_047202005.1 holo-ACP synthase -
N7921_RS02530 (N7921_02530) 523298..524314 + 1017 WP_095407802.1 outer membrane lipoprotein carrier protein LolA -
N7921_RS02535 (N7921_02535) 524454..525620 + 1167 WP_263639938.1 alanine racemase -
N7921_RS02540 (N7921_02540) 525914..526195 + 282 WP_003214273.1 hypothetical protein Antitoxin
N7921_RS02545 (N7921_02545) 526200..526550 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
N7921_RS02550 (N7921_02550) 526668..527498 + 831 WP_024427375.1 RsbT co-antagonist protein RsbRA -
N7921_RS02555 (N7921_02555) 527503..527871 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
N7921_RS02560 (N7921_02560) 527874..528275 + 402 WP_024427376.1 anti-sigma regulatory factor -
N7921_RS02565 (N7921_02565) 528286..529293 + 1008 WP_095407804.1 PP2C family protein-serine/threonine phosphatase -
N7921_RS02570 (N7921_02570) 529353..529682 + 330 WP_017358393.1 anti-sigma factor antagonist -
N7921_RS02575 (N7921_02575) 529679..530167 + 489 WP_048240335.1 anti-sigma B factor RsbW -
N7921_RS02580 (N7921_02580) 530133..530921 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
N7921_RS02585 (N7921_02585) 530921..531520 + 600 WP_095407805.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T259569 WP_024425388.1 NZ_CP106652:526200-526550 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT259569 WP_003214273.1 NZ_CP106652:525914-526195 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References