Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3906611..3908182 Replicon chromosome
Accession NZ_CP104986
Organism Proteus mirabilis strain W47

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N7F34_RS17760 Protein ID WP_036908598.1
Coordinates 3906611..3907924 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag N7F34_RS17765 Protein ID WP_004249771.1
Coordinates 3907925..3908182 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7F34_RS17740 3901780..3902583 + 804 WP_004249775.1 energy transducer TonB -
N7F34_RS17745 3902637..3904598 - 1962 WP_012368635.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
N7F34_RS17750 3904630..3905559 - 930 WP_004246518.1 metallophosphoesterase -
N7F34_RS17755 3905744..3906208 - 465 WP_004249773.1 DUF1097 domain-containing protein -
N7F34_RS17760 3906611..3907924 - 1314 WP_036908598.1 type II toxin-antitoxin system HipA family toxin Toxin
N7F34_RS17765 3907925..3908182 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
N7F34_RS17770 3908331..3909695 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
N7F34_RS17775 3909833..3911473 - 1641 WP_004246512.1 membrane protein insertase YidC -
N7F34_RS17780 3911476..3911736 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
N7F34_RS17785 3911700..3912059 - 360 WP_004246510.1 ribonuclease P protein component -
N7F34_RS17790 3912077..3912220 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49669.80 Da        Isoelectric Point: 6.6588

>T259557 WP_036908598.1 NZ_CP104986:c3907924-3906611 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT259557 WP_004249771.1 NZ_CP104986:c3908182-3907925 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References