Detailed information of TA system TA259555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3226562..3228284
• Replicon: chromosome
• Accession: NZ_CP104986
• Organism: Proteus mirabilis strain W47

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0U2S2I2
• Locus tag: N7F34_RS14755
• Protein ID: WP_064497040.1
• Coordinates: 3226562..3227500 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: N7F34_RS14760
• Protein ID: WP_000095577.1
• Coordinates: 3227493..3228284 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N7F34_RS14735	3222503..3223015	-	513	WP_175215521.1	S26 family signal peptidase	-
N7F34_RS14740	3222999..3223346	-	348	WP_064497038.1	hypothetical protein	-
N7F34_RS14745	3223339..3225738	-	2400	WP_064497039.1	type IV secretion system protein TraC	-
N7F34_RS14750	3225738..3226430	-	693	WP_001228924.1	DsbC family protein	-
N7F34_RS14755	3226562..3227500	-	939	WP_064497040.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N7F34_RS14760	3227493..3228284	-	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
N7F34_RS14765	3228505..3228891	-	387	WP_032469918.1	TraA family conjugative transfer protein	-
N7F34_RS14770	3228888..3229460	-	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
N7F34_RS14775	3229535..3230824	-	1290	WP_064497041.1	TraB/VirB10 family protein	-
N7F34_RS14780	3230827..3231723	-	897	WP_064497055.1	type-F conjugative transfer system secretin TraK	-
N7F34_RS14785	3231707..3232333	-	627	WP_064497042.1	TraE/TraK family type IV conjugative transfer system protein	-
N7F34_RS14790	3232330..3232611	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / aadA2 / ere(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aph(3')-Ia / tet(C) / sul2 / aph(3'')-Ib / aph(6)-Id / floR	-	3107323..3303178	195855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-272)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35542.81 Da
• Isoelectric Point: 4.9912

>T259555 WP_064497040.1 NZ_CP104986:c3227500-3226562 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT259555 WP_000095577.1 NZ_CP104986:c3228284-3227493 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

Structures

Toxin

• AlphaFold DB: A0A0U2S2I2