Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3618773..3619393 Replicon chromosome
Accession NZ_CP104976
Organism Enterobacter sp. 155105

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag N8O08_RS17460 Protein ID WP_148244022.1
Coordinates 3619175..3619393 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag N8O08_RS17455 Protein ID WP_008499288.1
Coordinates 3618773..3619147 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8O08_RS17445 (N8O08_17445) 3613900..3615093 + 1194 WP_223562619.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N8O08_RS17450 (N8O08_17450) 3615116..3618262 + 3147 WP_223562618.1 multidrug efflux RND transporter permease subunit AcrB -
N8O08_RS17455 (N8O08_17455) 3618773..3619147 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
N8O08_RS17460 (N8O08_17460) 3619175..3619393 + 219 WP_148244022.1 HHA domain-containing protein Toxin
N8O08_RS17465 (N8O08_17465) 3619599..3620150 + 552 WP_223562617.1 maltose O-acetyltransferase -
N8O08_RS17470 (N8O08_17470) 3620268..3620735 + 468 WP_223562616.1 YlaC family protein -
N8O08_RS17475 (N8O08_17475) 3620707..3622167 - 1461 WP_223562615.1 PLP-dependent aminotransferase family protein -
N8O08_RS17480 (N8O08_17480) 3622269..3622979 + 711 WP_223562614.1 GNAT family protein -
N8O08_RS17485 (N8O08_17485) 3622976..3623116 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N8O08_RS17490 (N8O08_17490) 3623119..3623379 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8646.02 Da        Isoelectric Point: 8.9008

>T259553 WP_148244022.1 NZ_CP104976:3619175-3619393 [Enterobacter sp. 155105]
MSDKPLTKFDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT259553 WP_008499288.1 NZ_CP104976:3618773-3619147 [Enterobacter sp. 155105]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References