Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2703235..2703858 Replicon chromosome
Accession NZ_CP104973
Organism Phyllobacterium zundukense strain A18/3m

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E88_RS25645 Protein ID WP_262293050.1
Coordinates 2703235..2703414 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E88_RS25650 Protein ID WP_262293051.1
Coordinates 2703463..2703858 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E88_RS25620 (N8E88_25625) 2698920..2699579 + 660 WP_262293046.1 dihydrofolate reductase family protein -
N8E88_RS25625 (N8E88_25630) 2699620..2699973 - 354 WP_262295625.1 CAP-Gly domain protein -
N8E88_RS25630 (N8E88_25635) 2700229..2701512 - 1284 WP_262293047.1 hypothetical protein -
N8E88_RS25635 (N8E88_25640) 2701549..2701953 + 405 WP_262293048.1 hypothetical protein -
N8E88_RS25640 (N8E88_25645) 2702172..2703155 + 984 WP_262293049.1 NAD(P)-dependent oxidoreductase -
N8E88_RS25645 (N8E88_25650) 2703235..2703414 + 180 WP_262293050.1 type II toxin-antitoxin system HicA family toxin Toxin
N8E88_RS25650 (N8E88_25655) 2703463..2703858 + 396 WP_262293051.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8E88_RS25655 (N8E88_25660) 2704182..2704991 + 810 WP_262293052.1 VOC family protein -
N8E88_RS25660 (N8E88_25665) 2705415..2706731 - 1317 WP_262293053.1 adenylosuccinate lyase -
N8E88_RS25665 (N8E88_25670) 2706826..2707555 - 730 Protein_2613 DUF2259 domain-containing protein -
N8E88_RS25670 (N8E88_25675) 2707552..2708229 - 678 WP_262293054.1 ribulose-phosphate 3-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-124)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6597.65 Da        Isoelectric Point: 10.4638

>T259544 WP_262293050.1 NZ_CP104973:2703235-2703414 [Phyllobacterium zundukense]
MPKPEIVARLEAEGWINVGGGNHDRFIHKDRPELMIPVPRHRELSPGTARSIAKAAGWM

Download         Length: 180 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13368.28 Da        Isoelectric Point: 4.4549

>AT259544 WP_262293051.1 NZ_CP104973:2703463-2703858 [Phyllobacterium zundukense]
MTYYVGILDGTGAVWGVRIPDVSGCVGAGASPEQAIADVTIALRDVMAHRRGGGFEIPAPSSVSAILASGEIQAGETIVM
IPLVLDSGRTVRANLTMDAGLLDAIDEAATLRGVTRSAFVASAAREKIEAA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References