Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2363656..2364272 Replicon chromosome
Accession NZ_CP104973
Organism Phyllobacterium zundukense strain A18/3m

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E88_RS23955 Protein ID WP_262292771.1
Coordinates 2363656..2363937 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8E88_RS23960 Protein ID WP_262292772.1
Coordinates 2363934..2364272 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E88_RS23935 (N8E88_23940) 2358899..2360056 + 1158 WP_262292767.1 putative lipid II flippase FtsW -
N8E88_RS23940 (N8E88_23945) 2360060..2361187 + 1128 WP_262292768.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -
N8E88_RS23945 (N8E88_23950) 2361184..2362584 + 1401 WP_262292769.1 UDP-N-acetylmuramate--L-alanine ligase -
N8E88_RS23950 (N8E88_23955) 2362630..2363604 + 975 WP_262292770.1 UDP-N-acetylmuramate dehydrogenase -
N8E88_RS23955 (N8E88_23960) 2363656..2363937 + 282 WP_262292771.1 type II toxin-antitoxin system HicA family toxin Toxin
N8E88_RS23960 (N8E88_23965) 2363934..2364272 + 339 WP_262292772.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8E88_RS23965 (N8E88_23970) 2364489..2365415 + 927 WP_262292773.1 D-alanine--D-alanine ligase -
N8E88_RS23970 (N8E88_23975) 2365403..2366344 + 942 WP_262292774.1 cell division protein FtsQ/DivIB -
N8E88_RS23975 (N8E88_23980) 2366341..2367663 + 1323 WP_262292775.1 cell division protein FtsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(32-84)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10444.18 Da        Isoelectric Point: 11.0200

>T259542 WP_262292771.1 NZ_CP104973:2363656-2363937 [Phyllobacterium zundukense]
MVLKNGTQFMKRKHHITLMQIFARPVSGSVRWVDVEALFVGLGVEISEREGSRVGVVLFGEVRVFHRPHPSPDTDKGAIA
SIRKWLESHGVKP

Download         Length: 282 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12045.79 Da        Isoelectric Point: 4.7341

>AT259542 WP_262292772.1 NZ_CP104973:2363934-2364272 [Phyllobacterium zundukense]
MKNVIDIDGHKAVVSLDPEIGMIRGEFLGLSGGADFYARSVDDLIVEGRKSLKVFLEMCAEKGIPPFREFSGRFNVRLAA
EVHEAAVLAAAAENKSLNEWVADAIEAAARAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References