Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 591973..592553 Replicon plasmid p_unnamed1
Accession NZ_CP104972
Organism Phyllobacterium zundukense strain A18/3m

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N8E88_RS10410 Protein ID WP_106713775.1
Coordinates 592170..592553 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N8E88_RS10405 Protein ID WP_106667672.1
Coordinates 591973..592173 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E88_RS10395 (N8E88_10405) 588966..589742 + 777 WP_262291683.1 ATP-binding cassette domain-containing protein -
N8E88_RS10400 (N8E88_10410) 590136..591166 - 1031 Protein_593 IS110 family transposase -
N8E88_RS10405 (N8E88_10415) 591973..592173 + 201 WP_106667672.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N8E88_RS10410 (N8E88_10420) 592170..592553 + 384 WP_106713775.1 type II toxin-antitoxin system VapC family toxin Toxin
N8E88_RS10415 (N8E88_10425) 593271..593534 + 264 WP_262291684.1 alpha-hydroxy-acid oxidizing protein -
N8E88_RS10420 (N8E88_10430) 593711..594496 - 786 WP_262291685.1 DUF3313 domain-containing protein -
N8E88_RS10425 (N8E88_10435) 594766..596097 - 1332 WP_262291686.1 HAMP domain-containing sensor histidine kinase -
N8E88_RS10430 (N8E88_10440) 596103..596774 - 672 WP_262292406.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - flhA / fliQ / fliP / htpB 1..990469 990469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14056.24 Da        Isoelectric Point: 7.0621

>T259537 WP_106713775.1 NZ_CP104972:592170-592553 [Phyllobacterium zundukense]
VILADTSIWIDHFRRVDAELRRIIEDDLLLCHPAVIGELALGSLRDRGSVIAFLAAQRAAVVATHDEVMTMIDRHSLFSI
GIGYTDAHLLASVLLDQRATLWTRDKRLRAAAEKAGASLHLPVNRPN

Download         Length: 384 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7142.24 Da        Isoelectric Point: 10.9613

>AT259537 WP_106667672.1 NZ_CP104972:591973-592173 [Phyllobacterium zundukense]
MRSTINLDDTLMEKARFLTGTNETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References