Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 536988..537652 Replicon plasmid p_unnamed2
Accession NZ_CP104971
Organism Phyllobacterium zundukense strain A18/3m

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N8E88_RS07205 Protein ID WP_262291297.1
Coordinates 537260..537652 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N8E88_RS07200 Protein ID WP_262291296.1
Coordinates 536988..537248 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E88_RS07170 (N8E88_07180) 532296..532520 + 225 WP_114431013.1 hypothetical protein -
N8E88_RS07175 (N8E88_07185) 532579..533373 + 795 WP_262291291.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
N8E88_RS07180 (N8E88_07190) 533401..534039 - 639 WP_262291292.1 maleylacetoacetate isomerase -
N8E88_RS07185 (N8E88_07195) 534036..535055 - 1020 WP_262291293.1 fumarylacetoacetate hydrolase family protein -
N8E88_RS07190 (N8E88_07200) 535052..536386 - 1335 WP_262291294.1 homogentisate 1,2-dioxygenase -
N8E88_RS07195 (N8E88_07205) 536469..536921 + 453 WP_262291295.1 MarR family transcriptional regulator -
N8E88_RS07200 (N8E88_07210) 536988..537248 + 261 WP_262291296.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N8E88_RS07205 (N8E88_07215) 537260..537652 + 393 WP_262291297.1 type II toxin-antitoxin system VapC family toxin Toxin
N8E88_RS07210 (N8E88_07220) 537649..538410 - 762 WP_114431006.1 ABC transporter permease -
N8E88_RS07215 (N8E88_07225) 538407..539333 - 927 WP_262291298.1 ABC transporter ATP-binding protein -
N8E88_RS07220 (N8E88_07230) 539531..540751 - 1221 WP_262291299.1 MFS transporter -
N8E88_RS07225 (N8E88_07235) 540881..541708 + 828 WP_262291300.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..586768 586768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13970.28 Da        Isoelectric Point: 9.1231

>T259534 WP_262291297.1 NZ_CP104971:537260-537652 [Phyllobacterium zundukense]
MLDTNAVSLAIKGNAATVKRMVDIPMASICISVVTEAELLFGLAKRPAATKLSSRIHEFLKRVNSLPLDSTVAARYGPLR
AQLEQRGRAIIGLDLLIAAHAIAANAILVSNDAAFRHVEGLQVEDWSKDP

Download         Length: 393 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9685.59 Da        Isoelectric Point: 4.1735

>AT259534 WP_262291296.1 NZ_CP104971:536988-537248 [Phyllobacterium zundukense]
MTQTAKIFTNGRSQAVRLPAAYRFDSSEVFIRRDEVTGDVILSSKPDNWDGFLAALREGDVPADFLSREERNLSGSDTDP
FEGWEE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References