Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 672396..673876 Replicon plasmid p_unnamed1
Accession NZ_CP104967
Organism Phyllobacterium sp. A18/5-2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag N8E89_RS21795 Protein ID WP_262263182.1
Coordinates 672620..673876 (+) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag N8E89_RS21790 Protein ID WP_262263181.1
Coordinates 672396..672623 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E89_RS21765 (N8E89_21760) 667993..668736 + 744 WP_262263176.1 GntR family transcriptional regulator -
N8E89_RS21770 (N8E89_21765) 668756..670003 + 1248 WP_262263177.1 kynureninase -
N8E89_RS21775 (N8E89_21770) 670000..670839 + 840 WP_262263178.1 tryptophan 2,3-dioxygenase -
N8E89_RS21780 (N8E89_21775) 670836..671513 - 678 WP_262263179.1 hypothetical protein -
N8E89_RS21785 (N8E89_21780) 671726..671929 - 204 WP_262263180.1 hypothetical protein -
N8E89_RS21790 (N8E89_21785) 672396..672623 + 228 WP_262263181.1 helix-turn-helix domain-containing protein Antitoxin
N8E89_RS21795 (N8E89_21790) 672620..673876 + 1257 WP_262263182.1 type II toxin-antitoxin system HipA family toxin Toxin
N8E89_RS21800 (N8E89_21795) 674410..674657 - 248 Protein_672 hypothetical protein -
N8E89_RS21805 (N8E89_21800) 674887..676206 - 1320 WP_262263183.1 NAD(P)H-dependent oxidoreductase -
N8E89_RS21810 (N8E89_21805) 676262..677269 - 1008 WP_262263184.1 aldose epimerase family protein -
N8E89_RS21815 (N8E89_21810) 677176..678249 - 1074 WP_262263185.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliP / flgI / fliI / motA / gmd / htpB / flhA / fliQ 1..1594332 1594332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-351)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 419 a.a.        Molecular weight: 44686.05 Da        Isoelectric Point: 5.0123

>T259531 WP_262263182.1 NZ_CP104967:672620-673876 [Phyllobacterium sp. A18/5-2]
MTHMLDVYYRQEKAGALSQEDDGALSFAYDAGYLGGSEPSAISSSMPLQEAAYGDRIVRPFFSGLLPDEGARQRLAGALG
ISSGNAFGLLEVIGGECAGALSLYPAGEAPPSSDDDGVEVLSRERLEEILGKLRERPLLGGEEGVRLSLAGAQDKLAVCA
EGENIGLAKGGRPTTHILKPFIQALDGTVENELFCLRLAARLGLPVPNVEMRHGATPFLLVERYDRARHEDGTITRLHQE
DFCQALSVPPELKYEAEGGPGTEASLALIGRATAHPAADRLGFIRMLILHYLVGNADAHGKNYALLYSGGIPDLAPLYDV
LCTAAYPRLDKKLAMAIGGRAVPDTIQLQQWLTLVPDTRGAQRLLVKAIAELAGRIGGQADELLAEFAEGGITHEILKVI
RGVIGTRAEHLLRIIEKA

Download         Length: 1257 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8058.27 Da        Isoelectric Point: 10.9628

>AT259531 WP_262263181.1 NZ_CP104967:672396-672623 [Phyllobacterium sp. A18/5-2]
MQTIIDSKSFGLLIRAERKAQNLTQEQLAGLTGVGVRFLRELEAGKDSCQIGRALQVAATLGLRVSVGSRRESAS

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References