Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 352388..353058 Replicon plasmid p_unnamed1
Accession NZ_CP104967
Organism Phyllobacterium sp. A18/5-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N8E89_RS20205 Protein ID WP_262262964.1
Coordinates 352388..352792 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N8E89_RS20210 Protein ID WP_262262965.1
Coordinates 352789..353058 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E89_RS20175 (N8E89_20170) 347748..348140 + 393 WP_262262959.1 hypothetical protein -
N8E89_RS20180 (N8E89_20175) 348244..348807 - 564 WP_262262960.1 hypothetical protein -
N8E89_RS20185 (N8E89_20180) 348729..349562 - 834 WP_262262961.1 hypothetical protein -
N8E89_RS20190 (N8E89_20185) 349675..350472 - 798 WP_262262962.1 hypothetical protein -
N8E89_RS20195 (N8E89_20190) 350444..351238 - 795 WP_262262963.1 LysM domain-containing protein -
N8E89_RS20200 (N8E89_20195) 351601..352236 - 636 Protein_353 IS6 family transposase -
N8E89_RS20205 (N8E89_20200) 352388..352792 - 405 WP_262262964.1 type II toxin-antitoxin system VapC family toxin Toxin
N8E89_RS20210 (N8E89_20205) 352789..353058 - 270 WP_262262965.1 antitoxin Antitoxin
N8E89_RS20215 (N8E89_20210) 353270..353943 + 674 Protein_356 IS6 family transposase -
N8E89_RS20220 (N8E89_20215) 354293..354538 - 246 Protein_357 IS110 family transposase -
N8E89_RS20225 (N8E89_20220) 354529..354633 - 105 Protein_358 IS5/IS1182 family transposase -
N8E89_RS20230 (N8E89_20225) 354762..355398 - 637 Protein_359 glutamine cyclotransferase -
N8E89_RS20235 (N8E89_20230) 355431..356652 - 1222 Protein_360 helix-turn-helix domain-containing protein -
N8E89_RS20240 (N8E89_20235) 356788..357564 + 777 WP_262262966.1 DUF899 domain-containing protein -
N8E89_RS20245 (N8E89_20240) 357588..357869 + 282 WP_262262967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliP / flgI / fliI / motA / gmd / htpB / flhA / fliQ 1..1594332 1594332
- inside IScluster/Tn - - 351601..353943 2342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14177.45 Da        Isoelectric Point: 7.1336

>T259529 WP_262262964.1 NZ_CP104967:c352792-352388 [Phyllobacterium sp. A18/5-2]
VSKRYMLDTNIVSELARNPHGAVTRRIAEVGPDAICISIITAAELRYGCAKKGSPKLLAQIEAILGSLPVLALDVPADAE
YGGIRAELEAAGKPIGPNDLFIAAHAYALGAVLVTANTGEFTRIRALRIENWLG

Download         Length: 405 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10337.90 Da        Isoelectric Point: 5.6560

>AT259529 WP_262262965.1 NZ_CP104967:c353058-352789 [Phyllobacterium sp. A18/5-2]
MPQLRHHEQEPPREAKLFRNNKSQAVRIPADFELPGDRVMIHREGDRLIIEPVRRKNLLEVLAGLEPLGRADQFPEIDDT
LLPLKDIDL

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References