Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 24525..25261 Replicon plasmid pHNAH8130-1
Accession NZ_CP104927
Organism Klebsiella pasteurii strain AHM8C130-1I

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag N5863_RS29110 Protein ID WP_284659185.1
Coordinates 24779..25261 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag N5863_RS29105 Protein ID WP_284659184.1
Coordinates 24525..24791 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5863_RS29075 (N5863_29070) 20108..21255 + 1148 WP_284659196.1 IS3 family transposase -
N5863_RS29080 (N5863_29075) 21299..21862 + 564 WP_284659181.1 LuxR C-terminal-related transcriptional regulator -
N5863_RS29085 (N5863_29080) 21974..22459 - 486 WP_284659182.1 hypothetical protein -
N5863_RS29090 (N5863_29085) 22449..23180 - 732 WP_284659183.1 winged helix-turn-helix domain-containing protein -
N5863_RS29095 (N5863_29090) 23631..24170 + 540 Protein_22 hypothetical protein -
N5863_RS29100 (N5863_29095) 24195..24452 + 258 WP_284659201.1 hypothetical protein -
N5863_RS29105 (N5863_29100) 24525..24791 + 267 WP_284659184.1 DUF1778 domain-containing protein Antitoxin
N5863_RS29110 (N5863_29105) 24779..25261 + 483 WP_284659185.1 GNAT family N-acetyltransferase Toxin
N5863_RS29115 (N5863_29110) 25613..28564 + 2952 WP_050484548.1 hypothetical protein -
N5863_RS29120 (N5863_29115) 28548..29000 + 453 WP_072023797.1 response regulator -
N5863_RS29125 (N5863_29120) 28997..30157 + 1161 WP_110183785.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..92922 92922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17374.10 Da        Isoelectric Point: 8.3151

>T259518 WP_284659185.1 NZ_CP104927:24779-25261 [Klebsiella pasteurii]
MGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCNTGTKHVAGFYSLATGSVNHTEATGSLRRNM
PEPIPVIILARLAVDVSLLGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHRFMASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10156.60 Da        Isoelectric Point: 4.6787

>AT259518 WP_284659184.1 NZ_CP104927:24525-24791 [Klebsiella pasteurii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPHWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References